Desmoglein 2 Is Less Important than Desmoglein 3 for Keratinocyte Cohesion
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منابع مشابه
Desmoglein 2 Is Less Important than Desmoglein 3 for Keratinocyte Cohesion
Desmosomes provide intercellular adhesive strength required for integrity of epithelial and some non-epithelial tissues. Within the epidermis, the cadherin-type adhesion molecules desmoglein (Dsg) 1-4 and desmocollin (Dsc) 1-3 build the adhesive core of desmosomes. In keratinocytes, several isoforms of these proteins are co-expressed. However, the contribution of specific isoforms to overall ce...
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AIMS We determined the contribution of the desmosomal cadherin desmoglein-2 to cell-cell cohesion in cardiomyocytes. In the intercalated disc, providing mechanical strength and electrical communication between adjacent cardiomyocytes, desmoglein-2 is closely associated with N-cadherin and gap junctions. METHODS AND RESULTS We studied intercalated discs of HL-1 cardiomyocytes by immunostaining...
متن کاملPrognostic significance of desmoglein 2 and desmoglein 3 in esophageal squamous cell carcinoma.
OBJECTIVE Desmogleins (DSGs) are major members among the desmosomal cadherins critically involved in cell-cell adhesion and the maintenance of normal tissue architecture in epithelia. Reports exploring links of DSG family member expression with cancers are few and vary. The aim of this study was to investigate the ratio of DSG2 and DSG3 mRNA expression in esophageal squamous cell carcinoma (ESC...
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Desmosomal cadherins in humans involve three isoforms, each in two splicing variants, of desmocollin (DSC1-3) and four isoforms of desmoglein (DSG1-4). DSGs are transmembranous desmosomal adhesive glycoproteins, which are generally expressed in a differentiation-specific manner. The aim of this study was to measure intensities of expression of both DSG2 and DSG3 in basal cell carcinoma (BCC) an...
متن کاملGalectin-3 regulates desmoglein-2 and intestinal epithelial intercellular adhesion.
The desmosomal cadherins, desmogleins, and desmocollins mediate strong intercellular adhesion. Human intestinal epithelial cells express the desmoglein-2 isoform. A proteomic screen for Dsg2-associated proteins in intestinal epithelial cells identified a lectin referred to as galectin-3 (Gal3). Gal3 bound to N-linked β-galactosides in Dsg2 extracellular domain and co-sedimented with caveolin-1 ...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0053739